Tumor-specific transcript variants of cyclin D1 in mantle cell lymphoma and multiple myeloma with chromosome 11q13 abnormalities

•Mantle cell lymphoma and multiple myeloma with 11q13 abnormalities express Cyclin D1 transcript variants with longer 5′-UTRs. •Cyclin D1 transcript variants with longer 5′-UTRs encode normal-sized cyclin D1 protein. •Protein expression of the CCND1 transcript variants with longer 5′-UTRs is regulated by the mTOR/EIF4E pathway. Cyclin D1 (CCND1) overexpression is an early and unifying oncogenic event in mantle cell lymphoma (MCL) and multiple...