Is Desmin Propensity to Aggregate Part of its Protective Function?
Abstract
Desmin is the major protein component of the intermediate filaments (IFs) cytoskeleton in muscle cells, including cardiac. The accumulation of cleaved and misfolded desmin is a cellular hallmark of heart failure (HF). These desmin alterations are reversed by therapy, suggesting a causal role for the IFs in the development of HF. Though IFs are known to play a role in the protection from stress, a mechanistic model of how that occurs is currently...
Paper Details
Title
Is Desmin Propensity to Aggregate Part of its Protective Function?
Published Date
Feb 20, 2020
Journal
Volume
9
Issue
2
Pages
491 - 491
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