Glucagon-like peptide-1 receptor agonists decrease systemic Th2 inflammation in asthmatics

Glucagon-like peptide (GLP)- 1 receptor signaling decreases type 2 (Th2) airway inflammation in mice. GLP-1R agonists (GLP-1RAs) are widely prescribed for type II diabetes mellitus (T2DM). We sought to identify the impact of GLP-1RA use on systemic biomarkers of Th1 and Th2 airway inflammation in asthmatic patients with diabetes. We measured levels of IL-6, IL-8, sCD163, periostin, total IgE, IL-33 and sST2 in Partners HealthCare Biobank serum...