Tumour suppressor candidate 3 inhibits biological function and increases endoplasmic reticulum stress of melanoma cells WM451 by regulating AKT/GSK3‐β/β‐catenin pathway

Melanoma is a highly malignant and is a life‐threatening disease with no effective treatment currently. This study aims to evaluate the significance of TUSC3, an endoplasmic reticulum stress (ERS)‐inducible gene and explore its relationship with AKT/GSK3‐β/β‐catenin signalling pathway in melanoma cell WM451. We investigated TUSC3 expression in melanoma cell by qRT‐PCR, CCK‐8 and clonal formation assays were utilized to evaluate cell...