Cell Biochemistry and Function
Papers 2523
1 page of 253 pages (2,523 results)
#1Wei Liu (JLU: Jilin University)
#2Peng-cheng Liu (JLU: Jilin University)
Last. Ming Yan (JLU: Jilin University)
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#1Mingzhe Shao (SJTU: Shanghai Jiao Tong University)H-Index: 4
#2Muyu Yu (SJTU: Shanghai Jiao Tong University)
Last. Guangming Chen (SJTU: Shanghai Jiao Tong University)
view all 10 authors...
#1Behrad DarvishiH-Index: 4
#2Malihe SalehiH-Index: 1
Last. Leila FarahmandH-Index: 5
view all 7 authors...
#2Chunyan Zhu (USTC: University of Science and Technology of China)
Last. Chongyang Ye (USTC: University of Science and Technology of China)
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This work aims to investigate the function and mechanism of long non-coding RNA (lncRNA) cytoskeleton regulator RNA (CYTOR) in myocardial injury induced by sepsis. The sepsis-induced myocardial injury model in mice was established by intraperitoneal injection of LPS (10 mg/kg) in vivo, and cardiomyocyte H9c2 was treated with LPS to mimic sepsis in vitro. CYTOR expression and miR-24 expression were detected by qRT-PCR. After up-regulation or down-regulation of CYTOR and miR-24 expression in the H...
#1Bin WangH-Index: 2
#2Kai Song (ZJU: Zhejiang University)
Last. Aimin Huang (Fujian Medical University)H-Index: 10
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Activated Cdc42-associated kinase 1 (ACK1) expression is upregulated in hepatocellular carcinoma (HCC) tissues and other tumour tissues. However, the function and regulatory mechanism of ACK1 in HCC remains unclear. In this study, the expression of pTyr284-ACK1, pSer473-AKT and PTEN in HCC was detected by immunohistochemistry, and its clinicopathological significance was analysed. Then, ACK1-targeted small molecule inhibitors AIM-100 and Dasatinib were used to treat cells SK-Hep-1 and HepG2, and...
#2Xin Xu (Nanjing Medical University)
Last. YanPing Guan (Capital Medical University)
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Long non-coding RNA (lncRNA) LINC00899 is one kind cytoplasmic lncRNA, however, there is rarely little information about its function in physiological process. Here, we demonstrated that lncRNA LINC00899 was upregulated in acute myeloid leukaemia (AML) cells and was quite correlated with poor prognosis of AML patients. High expression of LINC00899 in AML cells could promote cell proliferation and inhibit cell apoptosis, and facilitate the progression of AML consequently both in vitro and in vivo...
#1Liying ZhuH-Index: 4
Last. Wei PanH-Index: 2
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Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide and the third most frequent cause of cancer-related death. The IRX5 transcription factor plays a different role in multiple cancers and contributes to the development of many tumours. However, little is known about the molecular mechanisms of IRX5 in HCC. In this study, we found that IRX5 was abnormally upregulated in HCC tissues compared with adjacent normal tissues. IRX5 promoted HCC cell proliferation and upregulated the...
#1Chao Chen (JLU: Jilin University)H-Index: 2
#2Xin Wang (PRC: China Medical University (PRC))
Last. Jiaming Zhu (JLU: Jilin University)H-Index: 1
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LncRNA RP11-363E7.4 has been shown to be downregulated in gastric cancer (GC), while the effect of lncRNA RP11-363E7.4 on GC and its potential molecular mechanisms is unclear. The purpose of this study was to explore the functional role and underlying molecular mechanisms of lncRNA RP11-363E7.4 involved in GC progress.To address the question, quantitative real-time PCR assay was performed to confirm lncRNA RP11-363E7.4 expression levels in GC tissues and cell lines. Cell proliferation, apoptosis...
#1Partha Mukhopadhyay (University of Louisville)H-Index: 15
#2Robert M. Greene (University of Louisville)H-Index: 22
Last. M. Michele Pisano (University of Louisville)H-Index: 22
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MicroRNAs (miRNAs) provide context-dependent transcriptional regulation of genes comprising signalling networks throughout the developing organism including morphogenesis of the embryonic neural tube (NT). Using a high-sensitivity, high-coverage microarray analysis platform, miRNA expression in the murine embryonic NT during the critical stages of its formation was examined. Analysis of a number of differentially expressed (DE) miRNAs enabled identification of several gene targets associated wit...
#1Jiaming WuH-Index: 1
#2Zhi-Heng ChenH-Index: 2
Last. Yuping PengH-Index: 1
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This study was aimed to explore the expression and biological function of circRNA_0005075 in gastric cancer (GC) progression and its underlying mechanism. First, the expression level of circRNA_0005075 and microRNA-431 (miR-431) in GC tissues were detected with the quantitative real-time polymerase chain reaction. In addition, after down-regulated the circRNA_0005075 expression by plasmid transfection in GC cells, the Cell Counting Kit-8 (CCK-8), EDU, transwell assay were conducted to evaluate t...
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