Natural variants of α-gliadin peptides within wheat proteins with reduced toxicity in coeliac disease

The only generally accepted treatment of coeliac disease (CD) is a lifelong gluten-free diet. Wheat gluten proteins include gliadins, low and high molecular weight glutenins. However, we have found significant structural variations within these protein families among different cultivars. To determine which structural motifs might be less toxic than others, we assessed five variants of α -gliadin immunodominant CD-toxic peptides synthesised as...