Original paper
Topoisomerase 1 cleavage complex enables pattern recognition and inflammation during senescence
Abstract
Cyclic cGMP-AMP synthase (cGAS) is a pattern recognition cytosolic DNA sensor that is essential for cellular senescence. cGAS promotes inflammatory senescence-associated secretory phenotype (SASP) through recognizing cytoplasmic chromatin during senescence. cGAS-mediated inflammation is essential for the antitumor effects of immune checkpoint blockade. However, the mechanism by which cGAS recognizes cytoplasmic chromatin is unknown. Here we show...
Paper Details
Title
Topoisomerase 1 cleavage complex enables pattern recognition and inflammation during senescence
Published Date
Feb 19, 2020
Journal
Volume
11
Issue
1
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