Original paper
Loss of H3K36 Methyltransferase SETD2 Impairs V(D)J Recombination during Lymphoid Development
Abstract
Repair of DNA double-stranded breaks (DSBs) during lymphocyte development is essential for V(D)J recombination and forms the basis of immunoglobulin variable region diversity. Understanding of this process in lymphogenesis has historically been centered on the study of RAG1/2 recombinases and a set of classical non-homologous end-joining factors. Much less has been reported regarding the role of chromatin modifications on this process. Here, we...
Paper Details
Title
Loss of H3K36 Methyltransferase SETD2 Impairs V(D)J Recombination during Lymphoid Development
Published Date
Mar 1, 2020
Journal
Volume
23
Issue
3
Pages
100941 - 100941
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Notes
History