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#1Ganna Oliynyk (KI: Karolinska Institutet)H-Index: 4
#2María Victoria Ruiz-Pérez (KI: Karolinska Institutet)H-Index: 1
Last.Janne Lehtiö (Science for Life Laboratory)H-Index: 32
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Summary In pediatric neuroblastoma, MYCN-amplification correlates to poor clinical outcome and new treatment options are needed for these patients. Identifying the metabolic adaptations crucial for tumor progression may be a promising strategy to discover novel therapeutic targets. Here, we have combined proteomics, gene expression profiling, functional analysis, and metabolic tracing to decipher the impact of MYCN on neuroblastoma cell metabolism. We found that high MYCN levels are correlated w...
#1Franck RaynaudH-Index: 3
#2Marco MinaH-Index: 11
Last.Giovanni CirielloH-Index: 24
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Summary Intra-tumor heterogeneity is frequently observed in cancers patients and it is associated with therapeutic resistance and disease relapse. However, its systematic assessment is still limited and often unfeasible. Here, we use a mathematical model of tumor progression to decipher how multiple clones emerge and organize into complex architectures. We found a trade-off between cancer cell alteration and proliferation rates that defines a transition between low and high heterogeneity, the la...
#1Xue Yuan (Stanford University)H-Index: 10
#2Quanchen Xu (Stanford University)
Last.Jill A. Helms (Stanford University)H-Index: 59
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Summary Epithelia of the oral cavity exhibit variations in morphologies and turnover rates. Are these differences related to environment or to region-specific stem cell populations? A lineage-tracing strategy allowed visualization of Wnt-responsive cells, and their progeny, in the hard and soft palates. In both anatomic locations, Wnt-responsive basal cells self-renewed and gave rise to supra-basal cells. Palatal injuries triggered an enlargement of this population, and their descendants were re...
#1Zehai Xu (Zhejiang University of Technology)H-Index: 10
#2Yufan Zhang (CMU: Carnegie Mellon University)
Last.Qinglin Liu (Ha Tai: Xiamen University)
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Summary Development of spinel oxides as low-cost and high efficiency catalysts is highly desirable, however, rational synthesis of efficient and stable spinel systems with precisely controlled structure and components remains challenging. We demonstrate the design of complex nanostructured cobalt-based bimetallic spinel catalysts for low temperature CO oxidation by a simple template-free method. The self-assembled multi-shell mesoporous spinel nanostructures provide high surface area (203.5 m2/g...
#1Wen-Bang Yu (ECUST: East China University of Science and Technology)
#2Qian Pan (ECUST: East China University of Science and Technology)
Last.Bang-Ce Ye (Zhejiang University of Technology)H-Index: 34
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Summary Cyclic lipopeptides (CLPs) antibiotics have a mechanism which causes membrane malfunction. Thus, mechanisms of bacterial resistance to CLPs are thought to modify cell surfaces. However, we found that bacterial resistance to CLPs was strongly related to energy metabolism. Using polymyxin B (PB) as a model of CLPs, we showed that PB causes malfunction of respiration and serious depletion of ATP, contributing to PB-induced cell death and carbon starvation. Glucose addition could maintain th...
#1D. Kacy Cullen (UPenn: University of Pennsylvania)H-Index: 21
#2Wisberty J. Gordián-Vélez (UPenn: University of Pennsylvania)H-Index: 1
Last.H. Isaac Chen (UPenn: University of Pennsylvania)H-Index: 15
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Summary Reestablishing cerebral connectivity is a critical part of restoring neuronal network integrity and brain function after trauma, stroke, and neurodegenerative diseases. Creating transplantable axon tracts in the laboratory is a unexplored strategy for overcoming the common barriers limiting axon regeneration in vivo, including growth-inhibiting factors and the limited outgrowth capacity of mature neurons in the brain. We describe the generation, phenotype, and connectivity of constrained...
#1Nathalia Moreno Cury (State University of Campinas)H-Index: 2
Last.Sinisa Dovat (PSU: Pennsylvania State University)H-Index: 19
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Summary Tubulin is one of the best validated anti-cancer targets, but most anti-tubulin agents have unfavorable therapeutic indexes. Here, we characterized the tubulin binding activity, the mechanism of action and the in vivo anti-leukemia efficacy of three 3,4,5-trimethoxy-N-acylhydrazones. We show that all compounds target the colchicine-binding site of tubulin and that none is substrate of ABC transporters. The crystal structure of the tubulin-bound N-(1'-naphthyl)-3,4,5-trimethoxybenzohydraz...
#1Lili Li (CUHK: The Chinese University of Hong Kong)H-Index: 25
#2Yichao Fan (CUHK: The Chinese University of Hong Kong)H-Index: 9
Last.Winnie Yeo (CUHK: The Chinese University of Hong Kong)H-Index: 50
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Summary Aberrant RAS signaling activation is common in cancers with even few Ras mutations, indicating alternative dysregulation other than genetic mutations. We identified a Ras GTPase-activating gene RASA5/SYNGAP1, at the common 6p21.3 deletion, methylated/downregulated in multiple carcinomas and different from other RASA family members (RASA1-RASA4), indicating its special functions in tumorigenesis. RASA5 mutations are rare, unlike other RASA members, while its promoter CpG methylation is fr...
#1Yinghui GuoH-Index: 16
#2Zuojun ZhangH-Index: 5
Last.Xiangang LuoH-Index: 4
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Summary Despite tremendous efforts have been devoted to investigating the analogy between the surface plasmon polariton and its spoof counterparts, it remains elusive that a single thin spoof plasmonic metalens realize wide-angle focusing and wide field-of-view (FOV) imaging. Here, we propose a spoof plasmonic metasurface that can impart arbitrary phase with high transmittance, which is comprised of two-dimensional (2D) gradient spoof-insulator-spoof waveguides. With the developed catenary field...
#1Jian-Qiao Jiang (University of Bordeaux)
#2Christel Chanseau (University of Bordeaux)H-Index: 2
Last.Marie-Christine Durrieu (University of Bordeaux)H-Index: 22
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Summary Microvesicles (MVs) are used by a variety types of cells in human body for intercellular communication, making them biomarkers of great potential for the early and non-evasive diagnosis of a spectrum of diseases. An integrated analysis including morphological, quantitative and compositional studies is most desirable for the clinical application of MV detection; however such integration is limited by the currently available analysis techniques. In this context, exploiting the phosphatidyl...
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