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#1Xin Shao (ZJU: Zhejiang University)H-Index: 3
#2Jie Liao (ZJU: Zhejiang University)H-Index: 3
Last.Xiaohui Fan (ZJU: Zhejiang University)H-Index: 24
view all 6 authors...
Summary Recent advancements in single-cell RNA sequencing (scRNA-seq) have facilitated the classification of thousands of cells through transcriptome profiling, wherein accurate cell-type identification is critical for mechanistic studies. In most of current analysis protocols, cell type-based cluster annotation is manually performed and heavily relies on prior knowledge, resulting in poor replicability of cell type annotation. This study aimed to introduce a single-cell Cluster-based automatic ...
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#1Tsai-Min Chen (AS: Academia Sinica)
#2Chih-Han Huang (NTU: National Taiwan University)
Last.Ming-Jing Hwang (NTU: National Taiwan University)H-Index: 25
view all 5 authors...
Summary Electrocardiograms (ECGs) are widely used to clinically detect cardiac arrhythmias (CAs). They are also being used to develop computer-assisted methods for heart disease diagnosis. We have developed a convolution neural network model to detect and classify CAs, using a large 12-lead ECG dataset (6,877 recordings) provided by the China Physiological Signal Challenge (CPSC) 2018. Our model, which was ranked first in the challenge competition, achieved a median overall F1-score of 0.84 for ...
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#1Heng Huang (University of California, Berkeley)H-Index: 1
#2Paolo D'Odorico (University of California, Berkeley)H-Index: 57
Summary In many regions of the world pollinator populations are rapidly declining, a trend that is expected to disrupt major ecosystem functions and services. These changes in pollinator abundance may be prone to critical transitions with abrupt shifts to a state strongly depleted both in pollinator and vegetation abundance. Here we develop a process-based model to investigate the effect of a positive pollinator-vegetation feedback, whereby an initial decline in plant density increases selfing t...
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#1Sung-Ju Cho (UNIST: Ulsan National Institute of Science and Technology)H-Index: 10
#2Dae-Eun Yu (UNIST: Ulsan National Institute of Science and Technology)
Last.Sang-Young Lee (UNIST: Ulsan National Institute of Science and Technology)H-Index: 38
view all 7 authors...
Summary Coupling thin Li metal anodes with high-capacity/high-voltage cathodes such as LiNi0.8Co0.1Mn0.1O2 (NCM811) is a promising way to increase lithium battery energy density. Yet, the realization of high-performance full cells remains a formidable challenge. Here, we demonstrate a new class of highly coordinated, nonflammable carbonate electrolytes based on lithium bis(fluorosulfonyl)imide (LiFSI) in propylene carbonate/fluoroethylene carbonate mixtures. Utilizing an optimal salt concentrati...
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#1Rajeevkumar R. Nair (NTNU: Norwegian University of Science and Technology)H-Index: 4
#2Stefan Blankvoort (NTNU: Norwegian University of Science and Technology)H-Index: 3
Last.Cliff Kentros (UO: University of Oregon)H-Index: 3
view all 4 authors...
Summary While a variety of remarkable molecular tools for studying neural circuits have recently been developed, the ability to deploy them in particular neuronal subtypes is limited by the fact that native promoters are almost never specific enough. We recently showed that one can generate transgenic mice with anatomical specificity surpassing that of native promoters by combining enhancers uniquely active in particular brain regions with a heterologous minimal promoter, an approach we call EDG...
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#1Zhijuan Wang (HAU: Huazhong Agricultural University)
#2Lixiang Wang (Henan University)
Last.Xia Li (HAU: Huazhong Agricultural University)H-Index: 7
view all 4 authors...
Abstract Legumes control nodule number through nodulation and autoregulation of nodulation (AON) pathways. Nodule Inception (NIN) is essential for rhizobial infection and nodule organogenesis in legumes. The GmNINa-miR172c-NNC1 (NMN) module, which consists of two positive regulators, GmNINa and miR172c, and a suppressor, NNC1, integrates both pathways. GmNINa activates miR172c to downregulate NNC1, leading to nodulation, while NNC1 inhibits miR172c expression, forming a negative feedback loop. G...
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#1Yuan ZhongH-Index: 7
#2Mao XiaH-Index: 7
Last.Zhi ZhouH-Index: 10
view all 8 authors...
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#1Song Fan (SYSU: Sun Yat-sen University)H-Index: 13
#2Tian Tian (Nanjing Medical University)H-Index: 11
Last.Jinsong Li (SYSU: Sun Yat-sen University)H-Index: 12
view all 31 authors...
Summary Cisplatin-based neoadjuvant chemotherapy has been shown to improve survival in patients with squamous cell carcinoma (SCC), but clinical biomarkers to predict chemosensitivity remains elusive. Here, we show the long noncoding RNA (lncRNA) LINC01011, which we termed cisplatin sensitivity-associated lncRNA(CISAL), controls mitochondrial fission and cisplatin sensitivity by inhibiting BRCA1 transcription in tongue SCC (TSCC) models. Mechanistically, we found CISAL directly binds the BRCA1 p...
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#1Yu XieH-Index: 14
#2Manajit SenguptaH-Index: 18
Last.Aron HabteH-Index: 8
view all 7 authors...
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#1Douglas J. MacKenzie (Glas.: University of Glasgow)H-Index: 2
#2Neil R. Robertson (Glas.: University of Glasgow)H-Index: 68
Last.Peter D. Adams (Glas.: University of Glasgow)H-Index: 43
view all 11 authors...
Summary Approximately 10% of human colorectal cancer (CRC) are associated with activated BRAFV600E mutation, typically in absence of APC mutation and often associated with a CpG Island Methylator (CIMP) phenotype. To protect from cancer, normal intestinal epithelial cells respond to oncogenic BRAFV600E by activation of intrinsic p53 and p16-dependent tumor suppressor mechanisms, such as cellular senescence. Conversely, CIMP is thought to contribute to bypass of these tumor suppressor mechanisms,...
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