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#1Marlene Cervantes (UCI: University of California, Irvine)H-Index: 7
#2Ignasi Forné (LMU: Ludwig Maximilian University of Munich)H-Index: 21
Last. Paolo Sassone-Corsi (UCI: University of California, Irvine)H-Index: 109
view all 6 authors...
Summary The transcription factor BMAL1 is a core element of the circadian clock that contributes to cyclic control of genes transcribed by RNA polymerase II. By using biochemical cellular fractionation and immunofluorescence analyses we reveal a previously uncharacterized nucleolar localization for BMAL1. We used an unbiased approach to determine the BMAL1 interactome by mass spectrometry and identified NOP58 as a prominent nucleolar interactor. NOP58, a core component of the box C/D small nucle...
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#1Bernard Charroux (AMU: Aix-Marseille University)H-Index: 13
#2Fabrice Daian (AMU: Aix-Marseille University)H-Index: 8
Last. Julien Royet (AMU: Aix-Marseille University)H-Index: 29
view all 3 authors...
Summary The phytopathogen Erwinia carotovora carotovora (Ecc) has been used successfully to decipher some of the mechanisms that regulate the interactions between Drosophila melanogaster and bacteria, mostly following forced association between the two species. How do Drosophila normally perceive and respond to the presence of Ecc is unknown. Using a fly feeding two-choice assay and video tracking, we show that Drosophila are first attracted but then repulsed by an Ecc contaminated solution. Whi...
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#1Safak Caglayan (Oslo University Hospital)
#2Adnan Hashim (Oslo University Hospital)
Last. Andreas Brech (Oslo University Hospital)H-Index: 4
view all 16 authors...
Summary Optic atrophy 1 (OPA1), a GTPase at the inner mitochondrial membrane involved in regulating mitochondrial fusion, stability and energy output, is known to be crucial for neural development: Opa1 heterozygous mice show abnormal brain development, and inactivating mutations in OPA1 are linked to human neurological disorders. Here, we used genetically modified human embryonic and patient-derived induced pluripotent stem cells and reveal that OPA1 haploinsufficiency leads to aberrant nuclear...
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#1Kazuhiro Sato (Okayama University)H-Index: 38
#2Makoto Ishii (Okayama University)H-Index: 1
Last. Keiichi MochidaH-Index: 36
view all 8 authors...
Summary Heading time is a key trait in cereals affecting the maturation period for optimal grain filling before harvest. Here, we aimed to understand the factors controlling heading time in barley (Hordeum vulgare). We characterized a set of 274 barley accessions collected worldwide by planting them for 20 seasons under different environmental conditions at the same location in Kurashiki, Japan. We examined interactions among accessions, known genetic factors, and an environmental factor to dete...
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#1Génesis Osorio-Toribio (UNAM: National Autonomous University of Mexico)
#2Miriam de J. Velásquez-Hernández (Graz University of Technology)H-Index: 1
Last. Isabel Abánades Lázaro (Glas.: University of Glasgow)H-Index: 7
view all 14 authors...
Summary The Sc(III) MOF-type MFM-300(Sc) is demonstrated in this study to be stable under physiological conditions (PBS), biocompatible (to human skin cells) and an efficient drug carrier for the long-term controlled release (through human skin) of antioxidant ferulate. MFM-300(Sc) also preserves the antioxidant pharmacological effects of ferulate while enhancing the bio-preservation of dermal skin fibroblasts, during the delivery process. These discoveries pave the way towards the extended use ...
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#1Wei Zheng (SYSU: Sun Yat-sen University)H-Index: 11
#2Lemin Jia (SYSU: Sun Yat-sen University)H-Index: 2
Last. Feng Huang (SYSU: Sun Yat-sen University)H-Index: 13
view all 3 authors...
Summary Vacuum-Ultraviolet (VUV) photon detection technology is an effective means for the exploration in the field of space science (monitoring the formation and evolution of solar storms), high-energy physics (dark matter detection), large-scale scientific facility (VUV free electron lasers) and electronic industry (high-resolution lithography). The advancement of this technology mainly depends on the performance optimization of VUV photodetectors. In this review, we introduced the research pr...
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#1Dong-Bing Cheng (Center for Excellence in Education)H-Index: 2
#2Xue‐Hao Zhang (HAU: Huazhong Agricultural University)
Last. Hao Wang (Center for Excellence in Education)H-Index: 29
view all 6 authors...
Summary In some malignant tumor, especially for pancreatic tumor, poor solid-tumor penetration of nanotherapeutics impedes their treatment efficacy. Herein, we develop a polymer-peptide conjugate with the deep tissue penetration ability, which undergoes a cascade process under ultrasound (US), including i) the singlet oxygen 1O2 is generated by P18, ii) the thioketal bond is cleaved by the 1O2, iii) the departure of PEG chains leads to the in situ self-assembly, and iv) the resultant self-assemb...
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#1Masato Maesako (Harvard University)H-Index: 11
#2Nicole M. Sekula (Harvard University)
Last. Oksana Berezovska (Harvard University)H-Index: 36
view all 6 authors...
Summary A change in Presenilin (PS)/γ-secretase activity is linked to essential biological events as well as to the progression of many diseases. However, not much is known about how PS/γ-secretase activity is spatiotemporally regulated in cells. One of the limitations is lack of tools to directly monitor dynamic behavior of the PS/γ-secretase in intact/live cells. Here we present successful development and validation of the Forster resonance energy transfer (FRET)-based biosensors that enable q...
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#1Maha Siouda (UCBL: Claude Bernard University Lyon 1)
#2Audrey D. Dujardin (UCBL: Claude Bernard University Lyon 1)
Last. Jean-Philippe Foy (UCBL: Claude Bernard University Lyon 1)H-Index: 6
view all 18 authors...
Summary Epigenetic deregulation of gene transcription is central to cancer cell plasticity and malignant progression, but remains poorly understood. We found that the uncharacterized epigenetic factor Chromodomain on Y-like 2 (CDYL2) is commonly over-expressed in breast cancer, and that high CDYL2 levels correlate with poor prognosis. Supporting a functional role for CDYL2 in malignancy, it positively regulated breast cancer cell migration, invasion, stem-like phenotypes, and epithelial-to-mesen...
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