Original paper
PERK-mediated expression of peptidylglycine α-amidating monooxygenase supports angiogenesis in glioblastoma
Abstract
PKR-like kinase (PERK) plays a significant role in inducing angiogenesis in various cancer types including glioblastoma. By proteomics analysis of the conditioned medium from a glioblastoma cell line treated with a PERK inhibitor, we showed that peptidylglycine α-amidating monooxygenase (PAM) expression is regulated by PERK under hypoxic conditions. Moreover, PERK activation via CCT020312 (a PERK selective activator) increased the cleavage and...
Paper Details
Title
PERK-mediated expression of peptidylglycine α-amidating monooxygenase supports angiogenesis in glioblastoma
Published Date
Feb 13, 2020
Journal
Volume
9
Issue
2
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Notes
History