Key Aspects of the Immunobiology of Haploidentical Hematopoietic Cell Transplantation

Hematopoietic stem cell transplantation from a haploidentical donor is increasingly used and has become a standard donor option for patients lacking an appropriately matched sibling or unrelated donor. Historically, prohibitive immunological barriers resulting from the high degree of HLA-mismatch included graft-versus-host disease (GVHD) and graft failure. These were overcome with increasingly sophisticated strategies to manipulate the sensitive...