A TGF-β– and p63-Responsive Enhancer Regulates IFN-κ Expression in Human Keratinocytes
Abstract
Type I IFNs have antiviral and immune-modulating activities. IFN-α/-β have very low basal expression levels but are strongly induced upon activation of pattern recognition receptors. In contrast, IFN-κ is constitutively expressed in uninfected keratinocytes and responds only weakly to pattern recognition receptor activation. IFN-κ expression has been implicated in the pathogenesis of inflammatory skin diseases and in limiting human...
Paper Details
Title
A TGF-β– and p63-Responsive Enhancer Regulates IFN-κ Expression in Human Keratinocytes
Published Date
Apr 1, 2020
Journal
Volume
204
Issue
7
Pages
1825 - 1835
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