Original paper
Autolysosomal degradation of cytosolic chromatin fragments antagonizes oxidative stress–induced senescence
Abstract
Oxidative stress-induced DNA damage, the senescence-associated secretory phenotype (SASP), and impaired autophagy all are general features of senescent cells. However, the cross-talk among these events and processes is not fully understood. Here, using NIH3T3 cells exposed to hydrogen peroxide stress, we show that stress-induced DNA damage provokes the SASP largely via cytosolic chromatin fragment (CCF) formation, which activates a cascade...
Paper Details
Title
Autolysosomal degradation of cytosolic chromatin fragments antagonizes oxidative stress–induced senescence
Published Date
Apr 1, 2020
Volume
295
Issue
14
Pages
4451 - 4463
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Notes
History