Epigenetic driver mutations in ARID1A shape cancer immune phenotype and immunotherapy
Volume: 130, Issue: 5, Pages: 2712 - 2726
Published: Apr 20, 2020
Abstract
Whether mutations in cancer driver genes directly affect cancer immune phenotype and T cell immunity remains a standing question. ARID1A is a core member of the polymorphic BRG/BRM-associated factor chromatin remodeling complex. ARID1A mutations occur in human cancers and drive cancer development. Here, we studied the molecular, cellular, and clinical impact of ARID1A aberrations on cancer immunity. We demonstrated that ARID1A aberrations...
Paper Details
Title
Epigenetic driver mutations in ARID1A shape cancer immune phenotype and immunotherapy
Published Date
Apr 20, 2020
Volume
130
Issue
5
Pages
2712 - 2726
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