DNA Bridging by the Homologous Recombination Component CtIP Investigated on the Single DNA Molecule Level

Double-stranded breaks (DSBs) are considered a potentially lethal form of DNA damage and requires immediate measures by the cell to avoid genomic instability and apoptosis. Homologous recombination (HR) is one of the key DSB repair mechanisms, which is usually activated in the S and G2 phases by various factors, including the human CtIP tetramer. CtIP is known to interact with DNA and plays a key role, together with the MRN complex, in the...