Who Owns Sepsis

Published on Feb 4, 2020in Annals of Internal Medicine19.315
· DOI :10.7326/M19-2966
Michael Klompas41
Estimated H-index: 41
(Brigham and Women's Hospital),
Tiffany M. Osborn26
Estimated H-index: 26
(WashU: Washington University in St. Louis),
Chanu Rhee15
Estimated H-index: 15
(Brigham and Women's Hospital)
  • References (9)
  • Citations (0)
#1Chanu Rhee (Harvard University)H-Index: 15
#2Raymund Dantes (Emory University)H-Index: 7
Last. Michael Klompas (Harvard University)H-Index: 41
view all 20 authors...
Importance Estimates from claims-based analyses suggest that the incidence of sepsis is increasing and mortality rates from sepsis are decreasing. However, estimates from claims data may lack clinical fidelity and can be affected by changing diagnosis and coding practices over time. Objective To estimate the US national incidence of sepsis and trends using detailed clinical data from the electronic health record (EHR) systems of diverse hospitals. Design, Setting, and Population Retrospective co...
170 CitationsSource
#1Vincent Liu (KP: Kaiser Permanente)H-Index: 19
#2Vikram Fielding-Singh (UCSF: University of California, San Francisco)H-Index: 2
Last. Gabriel J. Escobar (KP: Kaiser Permanente)H-Index: 51
view all 7 authors...
Rationale: Prior sepsis studies evaluating antibiotic timing have shown mixed results.Objectives: To evaluate the association between antibiotic timing and mortality among patients with sepsis receiving antibiotics within 6 hours of emergency department registration.Methods: Retrospective study of 35,000 randomly selected inpatients with sepsis treated at 21 emergency departments between 2010 and 2013 in Northern California. The primary exposure was antibiotics given within 6 hours of emergency ...
78 CitationsSource
#1Henry E. Wang (UAB: University of Alabama at Birmingham)H-Index: 41
#2Allison R. Jones (UAB: University of Alabama at Birmingham)H-Index: 5
Last. John P. Donnelly (UAB: University of Alabama at Birmingham)H-Index: 17
view all 3 authors...
Objectives:The emergency department is an important venue for initial sepsis recognition and care. We sought to determine contemporary estimates of the epidemiology of U.S. emergency department visits for sepsis.Design:Analysis of data from the National Hospital Ambulatory Medical Care Survey.Settin
22 CitationsSource
#1Christopher W. Seymour (University of Pittsburgh)H-Index: 27
#2Foster C. Gesten (NYSDOH: New York State Department of Health)H-Index: 14
Last. Mitchell M. Levy (Brown University)H-Index: 60
view all 10 authors...
BackgroundIn 2013, New York began requiring hospitals to follow protocols for the early identification and treatment of sepsis. However, there is controversy about whether more rapid treatment of sepsis improves outcomes in patients. MethodsWe studied data from patients with sepsis and septic shock that were reported to the New York State Department of Health from April 1, 2014, to June 30, 2016. Patients had a sepsis protocol initiated within 6 hours after arrival in the emergency department an...
268 CitationsSource
#1Peter M. C. Klein Klouwenberg (UU: Utrecht University)H-Index: 19
#2Olaf L. Cremer (UU: Utrecht University)H-Index: 25
Last. T Vanderpoll (UvA: University of Amsterdam)H-Index: 98
view all 8 authors...
Introduction A clinical suspicion of infection is mandatory for diagnosing sepsis in patients with a systemic inflammatory response syndrome. Yet, the accuracy of categorizing critically ill patients presenting to the intensive care unit (ICU) as being infected or not is unknown. We therefore assessed the likelihood of infection in patients who were treated for sepsis upon admission to the ICU, and quantified the association between plausibility of infection and mortality.
35 CitationsSource
#1Sarah A. Sterling (University of Mississippi)H-Index: 8
#2W. Ryan Miller (University of Mississippi)H-Index: 1
Last. Alan E. Jones (University of Mississippi)H-Index: 49
view all 5 authors...
Objectives: We sought to systematically review and meta-analyze the available data on the association between timing of antibiotic administration and mortality in severe sepsis and septic shock. Data Sources: A comprehensive search criteria was performed using a predefined protocol. Study Selection: Inclusion criteria: adult patients with severe sepsis or septic shock, reported time to antibiotic administration in relation to emergency department triage and/or shock recognition, and mortality. E...
128 CitationsSource
#1Ricard FerrerH-Index: 21
Last. Mitchell M. LevyH-Index: 60
view all 9 authors...
Objectives:Compelling evidence has shown that aggressive resuscitation bundles, adequate source control, appropriate antibiotic therapy, and organ support are cornerstone for the success in the treatment of patients with sepsis. Delay in the initiation of appropriate antibiotic therapy has been reco
458 CitationsSource
#1Thomas P. Lodise (Albany College of Pharmacy and Health Sciences)H-Index: 38
#2PatelNimish (Albany College of Pharmacy and Health Sciences)H-Index: 19
Last. Jessina C. McGregor (OSU: Oregon State University)H-Index: 25
view all 8 authors...
Although a growing number of studies have found a relationship between delayed appropriate antibiotic therapy and mortality, few have attempted to quantify the temporal association between delayed appropriate antibiotic therapy and mortality. This study was designed to measure the elapsed time associated with an increased risk of 30-day mortality among patients with Pseudomonas aeruginosa bacteremia. The retrospective cohort study was conducted among immunocompetent, adult patients with P. aerug...
190 CitationsSource
#1Anand KumarH-Index: 43
#2Daniel RobertsH-Index: 13
Last. Mary CheangH-Index: 24
view all 13 authors...
Objective:To determine the prevalence and impact on mortality of delays in initiation of effective antimicrobial therapy from initial onset of recurrent/persistent hypotension of septic shock.Design:A retrospective cohort study performed between July 1989 and June 2004.Setting:Fourteen intensive car
3,285 CitationsSource
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