Chanu Rhee
Harvard University
Intensive care medicineSeptic shockSepsisOrgan dysfunctionMedicine
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Publications 93
#1Jeffrey R. Strich (USPHS: United States Public Health Service)H-Index: 4
#2Emily Ricotta (NIH: National Institutes of Health)H-Index: 2
Last. John H. Powers (Leidos)H-Index: 20
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BACKGROUND: Ceftazidime-avibactam has in vitro activity against some carbapenem-resistant gram-negative infections (GNIs), and therefore may be a useful alternative to more toxic antibiotics such as colistin. Understanding ceftazidime-avibactam uptake and usage patterns would inform hospital formularies, stewardship, and antibiotic development. METHODS: A retrospective cohort study assessed inpatient encounters in the Vizient database. Ceftazidime-avibactam and colistin administrations were cate...
#2Chanu Rhee (Harvard University)H-Index: 15
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Sepsis, the syndrome of life-threatening organ dysfunction that complicates severe infection, is a leading cause of death and disability worldwide.1 A growing recognition of the enormous burden of sepsis has spurred numerous awareness campaigns, quality improvement initiatives and regulatory measures in recent years. Reliably tracking the burden of sepsis is challenging, however, because sepsis is a clinical syndrome based on a constellation of non-specific signs and symptoms and lacks a gold st...
#1Chanu RheeH-Index: 15
#2Michael Klompas (Harvard University)H-Index: 41
Last. Michael KlompasH-Index: 1
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Numerous studies suggest that the incidence of sepsis has been steadily increasing over the past several decades while mortality rates are falling. However, reliably assessing trends in sepsis epidemiology is challenging due to changing diagnosis and coding practices over time. Ongoing efforts by clinicians, administrators, policy makers, and patient advocates to increase sepsis awareness, screening, and recognition are leading to more patients being labeled with sepsis. Subjective clinical defi...
1 CitationsSource
#1Michael Klompas (Brigham and Women's Hospital)H-Index: 41
#2Tiffany M. Osborn (WashU: Washington University in St. Louis)H-Index: 26
Last. Chanu Rhee (Brigham and Women's Hospital)H-Index: 15
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#2Michael KlompasH-Index: 41
Last. Chanu RheeH-Index: 15
view all 9 authors...
#1Alissa J Cooper (Brigham and Women's Hospital)
#2Steven P. Keller (Brigham and Women's Hospital)H-Index: 4
Last. Chanu Rhee (Harvard University)H-Index: 15
view all 7 authors...
Rationale: There have been advances in both cancer and sepsis treatment over the past several decades, yet little is known about trends in sepsis-associated mortality in patients with versus withou...
#1Heather E. HsuH-Index: 10
#2Rui WangH-Index: 25
Last. Grace M. LeeH-Index: 47
view all 8 authors...
#1Heather E. Hsu (BMC: Boston Medical Center)H-Index: 10
#2Francisca Abanyie (CDC: Centers for Disease Control and Prevention)H-Index: 6
Last. Chanu Rhee (Harvard University)H-Index: 15
view all 21 authors...
Pediatric sepsis is a major public health concern, and robust surveillance tools are needed to characterize its incidence, outcomes, and trends. The increasing use of electronic health records (EHRs) in the United States creates an opportunity to conduct reliable, pragmatic, and generalizable population-level surveillance using routinely collected clinical data rather than administrative claims or resource-intensive chart review. In 2015, the US Centers for Disease Control and Prevention recruit...