Original paper

A computationally designed chimeric antigen receptor provides a small-molecule safety switch for T-cell therapy

Volume: 38, Issue: 4, Pages: 426 - 432
Published: Feb 3, 2020
Abstract
Approaches to increase the activity of chimeric antigen receptor (CAR)-T cells against solid tumors may also increase the risk of toxicity and other side effects. To improve the safety of CAR-T-cell therapy, we computationally designed a chemically disruptable heterodimer (CDH) based on the binding of two human proteins. The CDH self-assembles, can be disrupted by a small-molecule drug and has a high-affinity protein interface with minimal amino...
Paper Details
Title
A computationally designed chimeric antigen receptor provides a small-molecule safety switch for T-cell therapy
Published Date
Feb 3, 2020
Volume
38
Issue
4
Pages
426 - 432
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