MitoTimer-based high-content screen identifies two chemically-related benzothiophene derivatives that enhance basal mitophagy
Abstract
Mitochondrial turnover is required for proper cellular function. Both mitochondrial biogenesis and mitophagy are impaired in several degenerative and age-related diseases. The search for mitophagy activators recently emerged as a new therapeutical approach; however, there is a lack in suitable tools to follow mitochondrial turnover in a high-throughput manner. We demonstrate that the fluorescent protein, MitoTimer, is a reliable and robust probe...
Paper Details
Title
MitoTimer-based high-content screen identifies two chemically-related benzothiophene derivatives that enhance basal mitophagy
Published Date
Jan 31, 2020
Journal
Volume
477
Issue
2
Pages
461 - 475
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