Interaction of yeast Rad51 and Rad52 relieves Rad52-mediated inhibition of de novo telomere addition
Abstract
DNA double-strand breaks (DSBs) are toxic forms of DNA damage that must be repaired to maintain genome integrity. Telomerase can act upon a DSB to create a de novo telomere, a process that interferes with normal repair and creates terminal deletions. We previously identified sequences in Saccharomyces cerevisiae (SiRTAs; Sites of Repair-associated Telomere Addition) that undergo unusually high frequencies of de novo telomere addition, even when...
Paper Details
Title
Interaction of yeast Rad51 and Rad52 relieves Rad52-mediated inhibition of de novo telomere addition
Published Date
Feb 3, 2020
Journal
Volume
16
Issue
2
Pages
e1008608 - e1008608
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