Original paper
Constitutive Interferon Attenuates RIPK1/3-Mediated Cytokine Translation
Abstract
Receptor-interacting protein kinase 1 (RIPK1) and 3 (RIPK3) are well known for their capacity to drive necroptosis via mixed-lineage kinase-like domain (MLKL). Recently, RIPK1/3 kinase activity has been shown to drive inflammation via activation of MAPK signaling. However, the regulatory mechanisms underlying this kinase-dependent cytokine production remain poorly understood. In the present study, we establish that the kinase activity of RIPK1/3...
Paper Details
Title
Constitutive Interferon Attenuates RIPK1/3-Mediated Cytokine Translation
Published Date
Jan 1, 2020
Journal
Volume
30
Issue
3
Pages
699 - 713.e4
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Notes
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