Original paper

Penetrance of Parkinson's Disease in LRRK2 p.G2019S Carriers Is Modified by a Polygenic Risk Score

Volume: 35, Issue: 5, Pages: 774 - 780
Published: Jan 20, 2020
Abstract
Although the leucine-rich repeat kinase 2 p.G2019S mutation has been demonstrated to be a strong risk factor for PD, factors that contribute to penetrance among carriers, other than aging, have not been well identified.To evaluate whether a cumulative genetic risk identified in the recent genome-wide study is associated with penetrance of PD among p.G2019S mutation carriers.We included p.G2019S heterozygote carriers with European ancestry in...
Paper Details
Title
Penetrance of Parkinson's Disease in LRRK2 p.G2019S Carriers Is Modified by a Polygenic Risk Score
Published Date
Jan 20, 2020
Volume
35
Issue
5
Pages
774 - 780
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