Parkin deficiency perturbs striatal circuit dynamics
Abstract
Loss-of-function mutations in the parkin-encoding PARK2 gene are a frequent cause of young-onset, autosomal recessive Parkinson's disease (PD). Parkin knockout mice have no nigro-striatal neuronal loss but exhibit abnormalities of striatal dopamine transmission and cortico-striatal synaptic function. How these predegenerative changes observed in vitro affect neural dynamics at the intact circuit level, however, remains hitherto elusive. Here, we...
Paper Details
Title
Parkin deficiency perturbs striatal circuit dynamics
Published Date
Apr 1, 2020
Journal
Volume
137
Pages
104737 - 104737
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