Automated quantification of head-twitch response in mice via ear tag reporter coupled with biphasic detection

Head-twitch response (HTR) is a manifestation of the serotonergic system behavioral pharmacology commonly used as a proxy of psychedelic drug action in rodents.We developed a minimally invasive magnetic ear tag reporter and designed a detection system that performs a comprehensive characterization of each potential HTR event on an electromagnetic readout.Magnetic ear tags were easy to install and generally well tolerated by the animals. On the...