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Journal of Neuroscience Methods
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#1Rajikha Raja (Georgia Institute of Technology)
#2Arvind Caprihan (The Mind Research Network)H-Index: 30
Last.Vince D. Calhoun (Georgia Institute of Technology)H-Index: 93
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Abstract Background Vascular cognitive impairment and dementia (VCID) and Alzheimer's disease are predominant diseases among the aging population resulting in decline of various cognitive domains. Diffusion weighted MRI (DW-MRI) has been shown to be a promising aid in the diagnosis of such diseases. However, there are various models of DW-MRI and the interpretation of diffusion metrics depends on the model used in fitting data. Most previous studies are entirely based on parameters calculated fr...
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#1William H. WalkerH-Index: 5
#2Jacob R. Bumgarner (WVU: West Virginia University)
Last.A. Courtney DeVries (WVU: West Virginia University)H-Index: 1
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Abstract Background Cytokines are key signaling molecules within the immune system that regulate a host’s response to pathogens and neuronal damage. Aberrant cytokine signaling has been implicated in many neurological diseases. Therefore, accurately measuring cytokine concentrations within the brain is crucial. New method This study demonstrates that removing blood within brain vasculature via saline perfusion does not alter brain parenchymal cytokine protein concentrations or mRNA expression. R...
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Abstract Background Head-twitch response (HTR) is a manifestation of the serotonergic system behavioral pharmacology commonly used as a proxy of psychedelic drug action in rodents. New method We developed a minimally invasive magnetic ear tag reporter and designed a detection system that performs a comprehensive characterization of each potential HTR event on an electromagnetic readout. Results Magnetic ear tags were easy to install and generally well tolerated by the animals. On the low-thresho...
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Abstract Background Classification of parkinsonian symptoms, including tremor and bradykinesia, require the application of validated clinical rating scales which are inherently subjective. In this study, we assessed an objective measure of parkinsonian symptomology using automated analysis of hand gestures. New method We constructed and evaluated a hand and finger motion capture apparatus and analysis pipeline that recorded hand/finger motion of control subjects and patients with Parkinson's dis...
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#2Antonie J. van den Bogert (CSU: Cleveland State University)H-Index: 32
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Abstract Background System identification can be used to obtain a model of the human postural control system from experimental data in which subjects are mechanically perturbed while standing. However, unstable controllers were sometimes found, which obviously do not explain human balance and cannot be applied in control of humanoid robots. Eigenvalue constraints can be used to avoid unstable controllers. However, this method is hard to apply to highly nonlinear systems and large identification ...
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#1Parisa Forouzannezhad (FIU: Florida International University)H-Index: 2
#2Alireza Abbaspour (FIU: Florida International University)H-Index: 6
Last.Malek Adjouadi (FIU: Florida International University)H-Index: 23
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Abstract Background Diagnosis of early mild cognitive impairment (EMCI) as a prodromal stage of Alzheimer's disease (AD) and its delineation from the cognitively normal (CN), remains a challenging but essential step for the planning of early treatment. Although several studies have focused on the MCI diagnosis, this study introduces the early stage of MCI to assess more thoroughly the earliest signs of disease manifestation and progression. New method We used random forest feature selection mode...
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#1Boris Neumann (Humboldt University of Berlin)H-Index: 1
#2Boris NeumannH-Index: 7
Last.Norbert JakubowskiH-Index: 36
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Abstract Background Immunohistochemistry techniques represent a powerful tool to detect and quantify disease related proteins. Improvements were accomplished by tagged antibodies using laser ablation and inductively coupled plasma mass spectrometry (LA-ICP-MS). However, these approaches are effected by day-to-variations due to instrumental drift. New Method Brain tissue from line 62, a Parkinson’s disease model, and control mice were incubated with four antibodies relevant to the disease and sta...
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#1Krishnashis Chatterjee (VT: Virginia Tech)H-Index: 2
#2Cora M. Carman-Esparza (VT: Virginia Tech)
Last.Jennifer M. Munson (VT: Virginia Tech)H-Index: 8
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Abstract The brain consists of a complex network of cells and matrix that is kept cushioned and nourished by multiple types of fluids: cerebrospinal fluid, blood, and interstitial fluid. The movement of these fluids through the tissues has recently gained more attention due to implications in Alzheimer's Disease and glioblastoma. Therefore, methods to study these fluid flows are necessary and timely for the current study of neuroscience. Imaging modalities such as magnetic resonance imaging have...
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#2Tadhg Crowley (Charité)
Last.Volker Siffrin (Charité)H-Index: 20
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Abstract Background Molecular analyses of cell populations and single cells have been instrumental in the advancement of our understanding of the physiology and pathologic processes of the nervous system. However, the limitation of these methods is the dependence on a gentle, efficient and specific enrichment procedure for the target cell population. In particular, this has been challenging for tightly interconnected cells, for example central nervous system (CNS) endogenous cells such as astroc...
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#1Sanaz Nazari-Farsani (TYKS: Turku University Hospital)H-Index: 1
#2Mikko Nyman (TYKS: Turku University Hospital)H-Index: 6
Last.Lauri Nummenmaa (UTU: University of Turku)H-Index: 39
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Abstract Background Successful delineation of lesions in acute ischemic strokes (AIS) is crucial for increasing the likelihood of good clinical outcome for the patient. New methods We developed a fully automated method to localize and segment AIS lesions in variable locations for 192 multimodal 3D-magnetic resonance images (MRI) including 106 stroke and 86 healthy cases. The method works based on the Crawford-Howell t-test and comparison of stroke images to healthy controls. We then developed a ...
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