Original paper
Multimodal genomic features predict outcome of immune checkpoint blockade in non-small-cell lung cancer
Abstract
Despite progress in immunotherapy, identifying patients that respond has remained a challenge. Through analysis of whole-exome and targeted sequence data from 5,449 tumors, we found a significant correlation between tumor mutation burden (TMB) and tumor purity, suggesting that low tumor purity tumors are likely to have inaccurate TMB estimates. We developed a new method to estimate a corrected TMB (cTMB) that was adjusted for tumor purity and...
Paper Details
Title
Multimodal genomic features predict outcome of immune checkpoint blockade in non-small-cell lung cancer
Published Date
Jan 13, 2020
Journal
Volume
1
Issue
1
Pages
99 - 111
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Notes
History