Stability and Compatibility Studies of Levothyroxine Sodium in Solid Binary Systems—Instrumental Screening
Abstract
The influence of excipients on the stability of sodium levothyroxine pentahydrate (LTSS) under ambient conditions and thermal stress was evaluated. Since LTSS is a synthetic hormone with a narrow therapeutic index, the interactions of LTSS with excipients can lead to a drastic diminution of therapeutic activity. Ten commonly used pharmaceutical excipients with different roles in solid formulations were chosen as components for binary mixtures...
Paper Details
Title
Stability and Compatibility Studies of Levothyroxine Sodium in Solid Binary Systems—Instrumental Screening
Published Date
Jan 10, 2020
Journal
Volume
12
Issue
1
Pages
58 - 58
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