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Pharmaceutics
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Published in Pharmaceutics
Bahez Gareb1
Estimated H-index: 1
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Silke Posthumus + -3 AuthorsHenderik W. Frijlink47
Estimated H-index: 47
Infliximab (IFX) is an intravenously administered monoclonal antibody antagonizing the effects of tumor necrosis factor-alpha (TNF) systemically and is efficacious in the treatment of inflammatory bowel disease (IBD). However, studies suggest that the anti-inflammatory effects result from local immunomodulation in the inflamed regions. Furthermore, topical inhibition of TNF in IBD ameliorates inflammation. We therefore hypothesized that orally administered IFX targeted to the ileo-colonic region...
Published in Pharmaceutics
Xiaotian Xie1
Estimated H-index: 1
,
Haijun Wang4
Estimated H-index: 4
+ -3 AuthorsLimin Zhu35
Estimated H-index: 35
In this study, curcumin-loaded porous poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) were prepared and surface modified with red blood cell membranes (RBCM) to yield biomimetic RBCM-p-PLGA@Cur NPs. The NPs displayed a visible cell-membrane structure at their exterior and had a uniform size of 162 ± 3 nm. In vitro studies showed that drug release from non-porous PLGA NPs was slow and that much of the drug remained trapped in the NPs. In contrast, release was accelerated from the porous ...
Published in Pharmaceutics
Xiaoxiao Sun1
Estimated H-index: 1
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Nan Wang2
Estimated H-index: 2
+ -3 AuthorsFangfang Huang
Nano anti-cancer drug carriers loaded with antineoplastic drugs can achieve targeted drug delivery, which enriches drugs at tumor sites and reduces the toxic side effects in normal tissues. Mesoporous silica nanoparticles (MSN) are good nano drug carriers, as they have large specific surface areas, adjustable pore sizes, easily modifiable surfaces, and good biocompatibility. In this work, polyethyleneimine (PEI) grafted MSN were modified with folic acid (FA) as an active target molecule using ch...
Published in Pharmaceutics
Roberta Guagliardo1
Estimated H-index: 1
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Pieterjan Merckx1
Estimated H-index: 1
+ -3 AuthorsKoen Raemdonck27
Estimated H-index: 27
Two decades since the discovery of the RNA interference (RNAi) pathway, we are now witnessing the approval of the first RNAi-based treatments with small interfering RNA (siRNA) drugs. Nevertheless, the widespread use of siRNA is limited by various extra- and intracellular barriers, requiring its encapsulation in a suitable (nanosized) delivery system. On the intracellular level, the endosomal membrane is a major barrier following endocytosis of siRNA-loaded nanoparticles in target cells and inno...
Published in Pharmaceutics
Anca Onaciu2
Estimated H-index: 2
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Raluca Andrada Munteanu + -3 AuthorsIoana Berindan-Neagoe23
Estimated H-index: 23
Hydrogels represent 3D polymeric networks specially designed for various medical applications. Due to their porous structure, they are able to swollen and to entrap large amounts of therapeutic agents and other molecules. In addition, their biocompatibility and biodegradability properties, together with a controlled release profile, make hydrogels a potential drug delivery system. In vivo studies have demonstrated their effectiveness as curing platforms for various diseases and affections. In ad...
Published in Pharmaceutics
Waleed Mohammed-Saeid4
Estimated H-index: 4
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Abdalla H. Karoyo8
Estimated H-index: 8
+ -3 AuthorsIldiko Badea21
Estimated H-index: 21
β-cyclodextrin (βCD) has been widely explored as an excipient for pharmaceuticals and nutraceuticals as it forms stable host–guest inclusion complexes and enhances the solubility of poorly soluble active agents. To enhance intracellular drug delivery, βCD was chemically conjugated to an 18-carbon chain cationic gemini surfactant which undergoes self-assembly to form nanoscale complexes. The novel gemini surfactant-modified βCD carrier host (hereafter referred to as 18:1βCDg) was designed to comb...
Published in Pharmaceutics
Francisco Fernández-Campos6
Estimated H-index: 6
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Beatriz Clares Naveros17
Estimated H-index: 17
+ -3 AuthorsAna Cristina Calpena Campmany20
Estimated H-index: 20
Rhinosinusitis is a prevalent disorder with a severe impact on the health-related quality of life. Saponins of Cyclamen europaeum exert a clinically proven curative effect on rhinosinusitis symptoms when instilled into the nasal cavity, however, more extensive preclinical assessment is required to better characterize the efficacy of this botanical extract. This work evaluates the potential use of a natural freeze-dried extract of C. europaeum given as topical nasal administration. Permeation exp...
Published in Pharmaceutics
Khadijah Edueng3
Estimated H-index: 3
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Christel A. S. Bergström29
Estimated H-index: 29
+ -3 AuthorsDenny Mahlin15
Estimated H-index: 15
This study shows the importance of the chosen method for assessing the glass-forming ability (GFA) and glass stability (GS) of a drug compound. Traditionally, GFA and GS are established using in situ melt-quenching in a differential scanning calorimeter. In this study, we included 26 structurally diverse glass-forming drugs (i) to compare the GFA class when the model drugs were produced by spray-drying with that when melt-quenching was used, (ii) to investigate the long-term physical stability o...
Published in Pharmaceutics
Klaudia Siwowska3
Estimated H-index: 3
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Patrycja Guzik + -3 AuthorsU. Köster25
Estimated H-index: 25
Targeted radionuclide therapy with 177Lu- and 90Y-labeled radioconjugates is a clinically-established treatment modality for metastasized cancer. 47Sc is a therapeutic radionuclide that decays with a half-life of 3.35 days and emits medium-energy β−-particles. In this study, 47Sc was investigated, in combination with a DOTA-folate conjugate, and compared to the therapeutic properties of 177Lu-folate and 90Y-folate, respectively. In vitro, 47Sc-folate demonstrated effective reduction of folate re...
Published in Pharmaceutics
Eleonora Colombo1
Estimated H-index: 1
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Michele Biocotino + -3 AuthorsDaniele Passarella24
Estimated H-index: 24
The disaccharide trehalose is an autophagy inducer, but its pharmacological application is severely limited by its poor pharmacokinetics properties. Thus, trehalose was coupled via suitable spacers with squalene (in 1:2 and 1:1 stoichiometry) and with betulinic acid (1:2 stoichiometry), in order to yield the corresponding nanolipid-trehalose conjugates 1-Sq-mono, 2-Sq-bis and 3-Be-mono. The conjugates were assembled to produce the corresponding nano-assemblies (NAs) Sq-NA1, Sq-NA2 and Be-NA3. Th...
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