Elevated histone H3 citrullination is associated with increased Beclin1 expression in HBV‐related hepatocellular carcinoma

Citrullinated histone H3 (H3Cit) is the product of the conversion of peptidylarginine to citrulline in histone H3. We evaluated the H3Cit level in hepatitis B virus (HBV)‐related hepatocellular carcinoma (HCC) tissues and assessed its association with Beclin1 messenger RNA (mRNA) (a key autophagic regulator). The level of H3Cit was detected by a capture enzyme‐linked immunosorbent assay, while Beclin1 mRNA was determined by real‐time polymerase...