Characterization of the Role of Host Cellular Factor Histone Deacetylase 10 during HIV-1 Replication
Abstract
To date, a series of histone deacetylases have been documented to restrict HIV-1 replication at different steps. In this study, we identified histone deacetylase 10 (HDAC10) as an inhibitory factor against HIV-1 replication. Our results showed that endogenous HDAC10 is downregulated at the transcriptional level during HIV-1 replication. By knocking down HDAC10 in CD4+ T cells with specific shRNAs, we observed that the downregulation of HDAC10...
Paper Details
Title
Characterization of the Role of Host Cellular Factor Histone Deacetylase 10 during HIV-1 Replication
Published Date
Dec 26, 2019
Journal
Volume
12
Issue
1
Pages
28 - 28
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