Top1 and Top2 promote replication fork arrest at a programmed pause site

Programmed fork pausing is a complex process allowing cells to arrest replication forks at specific loci in a polar manner. Studies in budding yeast and other model organisms indicate that such replication fork barriers do not act as roadblocks passively impeding fork progression but rather elicit complex interactions between fork and barrier components. In this issue of Genes & Development , Shyian and colleagues (pp. 87–98) show that in...