Further delineation of the phenotypic spectrum associated with hemizygous loss‐of‐function variants in NONO

The non‐POU domain containing, octamer‐binding gene, NONO , is located on chromosome Xq13.1 and encodes a member of a small family of RNA and DNA binding proteins that perform a variety of tasks involved in RNA synthesis, transcriptional regulation and DNA repair. Hemizygous loss‐of‐function variants in NONO have been shown to cause mental retardation, X‐linked, syndromic 34 in males. Features of this disorder can include a range of...