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American Journal of Medical Genetics
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#1John M. Hettema (A&M: Texas A&M University)
#2Brad Verhulst (MSU: Michigan State University)H-Index: 14
Last. Murray B. Stein (UCSD: University of California, San Diego)H-Index: 130
view all 12 authors...
Anxiety disorders (ANX), namely generalized anxiety, panic disorder, and phobias, are common, etiologically complex syndromes that show increasing prevalence and comorbidity throughout adolescence and beyond. Few genome-wide association studies (GWAS) examining ANX risk have been published and almost exclusively in individuals of European ancestry. In this study, we phenotyped participants from the Army Study To Assess Risk and Resilience in Servicemembers (STARRS) to approximate DSM-based ANX d...
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#1Dirk J. A. SmitH-Index: 20
#2Danielle C. Cath (UMCG: University Medical Center Groningen)H-Index: 45
Last. Dorret I. Boomsma (VU: VU University Amsterdam)H-Index: 136
view all 10 authors...
We investigated whether obsessive-compulsive (OC) symptoms from a population-based sample could be analyzed to detect genetic variants influencing obsessive-compulsive disorder (OCD). We performed a genome-wide association studies (GWAS) on the obsession (rumination and impulsions) and compulsion (checking, washing, and ordering/precision) subscales of an abbreviated version of the Padua Inventory (N = 8,267 with genome-wide genotyping and phenotyping). The compulsion subscale showed a substanti...
2 CitationsSource
#1Jameson Patak (State University of New York Upstate Medical University)H-Index: 3
#2Stephen V. Faraone (State University of New York Upstate Medical University)H-Index: 164
Last. Yanli Zhang-James (State University of New York Upstate Medical University)H-Index: 13
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#1Marc Woodbury-Smith (Newcastle University)H-Index: 12
Last. JH Howe
view all 18 authors...
Autism spectrum disorder (ASD) is a relatively common childhood onset neurodevelopmental disorder with a complex genetic etiology. While progress has been made in identifying the de novo mutational landscape of ASD, the genetic factors that underpin the ASD's tendency to run in families are not well understood. In this study, nine extended pedigrees each with three or more individuals with ASD, and others with a lesser autism phenotype, were phenotyped and genotyped in an attempt to identify her...
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#1Bettina Meiser (UNSW: University of New South Wales)H-Index: 40
#2Xin Y. Guo (UNSW: University of New South Wales)
Last. Tatiane Yanes (UNSW: University of New South Wales)H-Index: 3
view all 7 authors...
The aim of this systematic review was to synthesize the existing evidence documenting the psychosocial implications of living with a familial risk of an adult-onset psychiatric disorder. Six databases were searched systematically to identify qualitative and quantitative studies, which explored perspectives of those at increased risk for psychiatric disorders, as well as the general public. Thematic analysis was used to identify major themes. Thirty-five articles met the eligibility criteria and ...
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#1Eshim Jami (PHRI: Public Health Research Institute)
#2Espen Moen Eilertsen (FHI: Norwegian Institute of Public Health)H-Index: 5
Last. Christel M. Middeldorp (UQ: University of Queensland)H-Index: 40
view all 8 authors...
It is unclear to what extent parental influences on the development of internalizing problems in offspring are explained by indirect genetic effects, reflected in the environment provided by the parent, in addition to the genes transmitted from parent to child. In this study, these effects were investigated using two innovative methods in a large birth cohort. Using maternal-effects genome complex trait analysis (M-GCTA), the effects of offspring genotype, maternal or paternal genotypes, and the...
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#1Patricia Mansfield (SLU: Saint Louis University)
#2John N. Constantino (WashU: Washington University in St. Louis)H-Index: 46
Last. Dustin Baldridge (WashU: Washington University in St. Louis)H-Index: 9
view all 3 authors...
Variations in MYT1L, a gene encoding a transcription factor expressed in the brain, have been associated with autism, intellectual disability, and schizophrenia. Here we provide an updated review of published reports of neuropsychiatric correlates of loss of function and duplication of MYT1L. Of 27 duplications all were partial; 33% were associated exclusively with schizophrenia, and the chromosomal locations of schizophrenia-associated duplications exhibited a distinct difference in pattern-of-...
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#1Philip D. Harvey (UM: University of Miami)H-Index: 86
#2Ning Sun (Yale University)H-Index: 11
Last. Larry J. Siever (Yale University)
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Cognitive impairment is a frequent and serious problem in patients with various forms of severe mental illnesses (SMI), including schizophrenia (SZ) and bipolar disorder (BP). Recent research suggests genetic links to several cognitive phenotypes in both SMI and in the general population. Our goal in this study was to identify potential genomic signatures of cognitive functioning in veterans with severe mental illness and compare them to previous findings for cognition across different populatio...
1 CitationsSource
#1Fanglin Guan (Xi'an Jiaotong University)H-Index: 12
#2Tong Ni (Xi'an Jiaotong University)H-Index: 3
Last. Tianxiao Zhang (Xi'an Jiaotong University)H-Index: 11
view all 9 authors...
WBP1L is a target of microRNA 137 (miR-137) and has been considered a candidate gene for schizophrenia (SCZ). To investigate the relationships between WBP1L and SCZ and its related symptom scales, a total of 5,993 Chinese Han subjects, including 2,128 SCZ patients and 3,865 controls, were enrolled. In addition, an independent sample set for replication study including 1,052 SCZ patients and 2,124 controls were also recruited. Thirty-two tag single nucleotide polymorphisms (SNPs) located within g...
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#1Khushnooda RamzanH-Index: 11
#2Mohammed Al-OwainH-Index: 24
Last. Faiqa ImtiazH-Index: 13
view all 15 authors...
Hearing loss (HL) is the most common sensory disorder worldwide and genetic factors contribute to approximately half of congenital HL cases. HL is subject to extensive genetic heterogeneity, rendering molecular diagnosis difficult. Mutations of the transmembrane channel-like 1 (TMC1) gene cause hearing defects in humans and mice. The precise function of TMC1 protein in the inner ear is unknown, although it is predicted to be involved in functional maturation of cochlear hair cells. TMC1 mutation...
1 CitationsSource
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