Original paper
Evidence for lysosomal biogenesis proteome defect and impaired autophagy in preeclampsia
Abstract
The etiology of preeclampsia (PE), a serious pregnancy complication, remains an enigma. We have demonstrated that proteinopathy, a pathologic feature of neurodegenerative diseases, is a key observation in the placenta and serum from PE patients. We hypothesize that the macroautophagy/autophagy machinery that mediates degradation of aggregated proteins and damaged organelles is impaired in PE. Here, we show that TFEB (transcription factor EB), a...
Paper Details
Title
Evidence for lysosomal biogenesis proteome defect and impaired autophagy in preeclampsia
Published Date
Dec 26, 2019
Journal
Volume
16
Issue
10
Pages
1771 - 1785
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Notes
History