Rapamycin persistently improves cardiac function in aged, male and female mice, even following cessation of treatment
Abstract
Even in healthy aging, cardiac morbidity and mortality increase with age in both mice and humans. These effects include a decline in diastolic function, left ventricular hypertrophy, metabolic substrate shifts, and alterations in the cardiac proteome. Previous work from our laboratory indicated that short-term (10-week) treatment with rapamycin, an mTORC1 inhibitor, improved measures of these age-related changes. In this report, we demonstrate...
Paper Details
Title
Rapamycin persistently improves cardiac function in aged, male and female mice, even following cessation of treatment
Published Date
Dec 10, 2019
Journal
Volume
19
Issue
2
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