Original paper

PRMT1 Is Required for the Maintenance of Mature β-Cell Identity

Volume: 69, Issue: 3, Pages: 355 - 368
Published: Mar 1, 2020
Abstract
Loss of functional β-cell mass is an essential feature of type 2 diabetes, and maintaining mature β-cell identity is important for preserving a functional β-cell mass. However, it is unclear how β-cells achieve and maintain their mature identity. Here we demonstrate a novel function of protein arginine methyltransferase 1 (PRMT1) in maintaining mature β-cell identity. Prmt1 knockout in fetal and adult β-cells induced diabetes, which was...
Paper Details
Title
PRMT1 Is Required for the Maintenance of Mature β-Cell Identity
Published Date
Mar 1, 2020
Journal
Volume
69
Issue
3
Pages
355 - 368
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