Original paper
Compromised steady‐state germinal center activity with age in nonhuman primates
Abstract
Age-related reductions in vaccine-induced B cells in aging indicate that germinal centers (GCs), the anatomical site where the development of humoral responses takes place, may lose efficacy with age. We have investigated the baseline follicular and GC composition in nonhuman primates (NHPs) with respect to their age. There was a marked reduction in follicular area in old animals. We found significantly lower normalized numbers of follicular...
Paper Details
Title
Compromised steady‐state germinal center activity with age in nonhuman primates
Published Date
Dec 15, 2019
Journal
Volume
19
Issue
2
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Notes
History