Primary and Metastatic Pancreatic Cancer Cells Exhibit Differential Migratory Potentials

Objectives Pancreatic ductal adenocarcinoma (PDAC) is characterized by early metastatic spread in more than 50% of patients. In this study, we sought to understand the migratory properties of (non)metastatic PDAC cells and determine whether the migration of cancer stem cell (CSC) populations accounts for the aggressive nature of this disease. Methods The migratory abilities of primary and metastatic PDAC cell lines were investigated using a...