Uterine Luminal Epithelium as the Transient Gateway for Embryo Implantation

Intrauterine fluid resorption, cessation of LE proliferation and apoptosis, and LE structural changes are prerequisites for the establishment of uterine receptivity. The receptive LE can sense intraluminal stimuli, most likely involving mechanosensors. Vesicle trafficking in LE, as well as estrogen (ERα)- and progesterone receptor (PR)-mediated paracrine and autocrine mechanisms, are crucial for LE remodeling and LE communications with the...