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Trends in Endocrinology and Metabolism
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9.78
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2836
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#1Tohru Hira (Hokkaido University)H-Index: 17
#2Jukkrapong Pinyo (Hokkaido University)H-Index: 2
Last.Hiroshi HaraH-Index: 42
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Glucagon-like peptide-1 (GLP-1) is a gastrointestinal hormone released in response to meal ingestion and enhances insulin secretion from pancreatic β cells. In several human studies, GLP-1 secretory responses to oral glucose load or a meal were decreased in subjects with obesity, glucose intolerance, or diabetes compared with those in healthy subjects. However, the results of meta-analysis and cohort studies do not necessarily support this concept. Results from animal studies are also inconsiste...
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#1Rasmus Kold-Christensen (AU: Aarhus University)H-Index: 1
#2Mogens Johannsen (AU: Aarhus University)H-Index: 25
Methylglyoxal (MG) is a ubiquitous metabolite that spontaneously reacts with biopolymers forming advanced glycation end-products (AGEs). AGEs are strongly associated with aging-related diseases, including cancer, neurodegenerative diseases, and diabetes. As the formation of AGEs is nonenzymatic, the damage caused by MG and AGEs has been regarded as unspecific. This may have resulted in the field generally been regarded as unappealing by many researchers, as detailed mechanisms have been difficul...
2 CitationsSource
#1Carina Bodden (Florey Institute of Neuroscience and Mental Health)
#2Anthony J. Hannan (University of Melbourne)H-Index: 45
Last.Amy C. Reichelt (UWO: University of Western Ontario)H-Index: 16
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Globally, obesity has reached epidemic proportions. The rapidly increasing numbers of overweight people can be traced back to overconsumption of energy-dense, poor-quality foods as well as physical inactivity. This development has far-reaching and costly implications. Not only is obesity associated with serious physiological and psychological complications, but mounting evidence also indicates a ripple effect through generations via epigenetic changes. Parental obesity could induce intergenerati...
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The uterine luminal epithelium (LE) is the first maternal contact for an implanting embryo. Intrauterine fluid resorption, cessation of LE proliferation and apoptosis, and LE structural changes are prerequisites for establishing transient uterine receptivity for embryo implantation. Vesicle trafficking in the LE and receptor-mediated paracrine and autocrine mechanisms are crucial both for LE preparation and LE communications with the embryo and stroma during the initiation of embryo implantation...
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#1Zahra Bahadoran (Shahid Beheshti University of Medical Sciences and Health Services)H-Index: 18
#2Parvin Mirmiran (Shahid Beheshti University of Medical Sciences and Health Services)H-Index: 44
Last.Asghar Ghasemi (Shahid Beheshti University of Medical Sciences and Health Services)H-Index: 21
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Nitric oxide (NO) contributes to carbohydrate metabolism and decreased NO bioavailability is involved in the development of type 2 diabetes mellitus (T2DM). NO donors may improve insulin signaling and glucose homeostasis in T2DM and insulin resistance (IR), suggesting the potential clinical importance of NO-based interventions. In this review, site-specific roles of the NO synthase (NOS)–NO pathway in carbohydrate metabolism are discussed. In addition, the metabolic effects of physiological low ...
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#1Alfonso Abizaid (Carleton University)H-Index: 26
#2James L. Hougland (SU: Syracuse University)H-Index: 12
Ghrelin and the growth hormone secretagogue receptor 1a (GHS-R1a) are important targets for disorders related to energy balance and metabolic regulation. Pharmacological control of ghrelin signaling is a promising avenue to address health issues involving appetite, weight gain, obesity, and related metabolic disorders, and may be an option for patients suffering from wasting conditions like cachexia. In this review, we summarize recent developments in the biochemistry of ghrelin and GHS-R1a sign...
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#1Jennifer SnaithH-Index: 2
#2D. J. Holmes-Walker (USYD: University of Sydney)H-Index: 8
Last.Jerry R. Greenfield (UNSW: University of New South Wales)H-Index: 36
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Individuals with type 1 diabetes (T1D) frequently fail to achieve glycemic goals and have excess cardiovascular risk and premature death. Adjunctive agents may play a role in reducing morbidity, mortality, and the adverse sequelae of insulin treatment. A surge in type 2 diabetes drug development has revealed agents with benefits beyond glucose lowering, including cardiovascular risk reduction. Could these benefits translate to T1D? Specific trials for T1D demonstrate substantial hemoglobin (Hb)A...
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#1Linjie Zhao (Sichuan University)H-Index: 8
#2Ryan C. Gimple (UCSD: University of California, San Diego)H-Index: 8
Last.Shengtao Zhou (Sichuan University)H-Index: 14
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Members of the nuclear receptor superfamily serve as master regulators in signaling by either positively or negatively regulating gene expression. Accumulating evidence has suggested that nuclear receptors are actively involved in immune responses, with specific roles in different immune cell compartments that contribute to both normal function and to disease development. The druggable properties of nuclear receptors have made them ideal modulatory therapeutic targets. Here, we revisit nuclear r...
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#1Claudia Bambs (UC: Pontifical Catholic University of Chile)H-Index: 11
#2Roberto Bravo-Sagua (INTA: International Trademark Association)
Last.Sergio Lavandero (Centro de Estudios Científicos)H-Index: 51
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Chile has experienced rapid epidemiological transitions characterized by decreasing infant mortality, population aging, and a shift towards obesity with an increase in noncommunicable diseases (NCDs). Today, tobacco, alcohol, and ultraprocessed foods are the main risk factors for these diseases. Based on Chile’s experience in tobacco control, we discuss paths to make progress in population evidence-based strategies to improve overall community health.
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#1Michaela C. Pascoe (VU: Victoria University, Australia)H-Index: 9
#2David R. Thompson (University of Melbourne)H-Index: 66
Last.Chantal F. Ski (University of Melbourne)H-Index: 18
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Top fields of study
Endocrinology
Diabetes mellitus
Hormone
Medicine
Biology