Ligand Entry into Fatty Acid Binding Protein via Local Unfolding Instead of Gap Widening
Abstract
Fatty acid binding proteins play an important role in the transportation of fatty acids. Despite intensive studies, how fatty acids enter the protein cavity for binding is still controversial. Here, a gap-closed variant of human intestinal fatty acid binding protein was generated by mutagenesis, in which the gap is locked by a disulfide bridge. According to its structure determined here by NMR, this variant has no obvious openings as the ligand...
Paper Details
Title
Ligand Entry into Fatty Acid Binding Protein via Local Unfolding Instead of Gap Widening
Published Date
Jan 1, 2020
Journal
Volume
118
Issue
2
Pages
396 - 402
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