Review paper
CD13/Aminopeptidase N Is a Potential Therapeutic Target for Inflammatory Disorders
Abstract
CD13/aminopeptidase N is a widely expressed ectoenzyme with multiple functions. As an enzyme, CD13 regulates activities of numerous cytokines by cleaving their N-terminals and is involved in Ag processing by trimming the peptides bound to MHC class II. Independent of its enzymatic activity, cell membrane CD13 functions by cross-linking–induced signal transduction, regulation of receptor recycling, enhancement of FcγR-mediated phagocytosis, and...
Paper Details
Title
CD13/Aminopeptidase N Is a Potential Therapeutic Target for Inflammatory Disorders
Published Date
Jan 1, 2020
Journal
Volume
204
Issue
1
Pages
3 - 11
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