CD13/Aminopeptidase N Is a Potential Therapeutic Target for Inflammatory Disorders

CD13/aminopeptidase N is a widely expressed ectoenzyme with multiple functions. As an enzyme, CD13 regulates activities of numerous cytokines by cleaving their N-terminals and is involved in Ag processing by trimming the peptides bound to MHC class II. Independent of its enzymatic activity, cell membrane CD13 functions by cross-linking–induced signal transduction, regulation of receptor recycling, enhancement of FcγR-mediated phagocytosis, and...