Oral repeated-dose toxicity studies of BIA 10–2474 in CD-1 mice

We independently and retrospectively reviewed three studies that evaluated the toxicity of BIA 10–2474 (3-(1-(cyclohexyl(methyl)carbamoyl)-lH-imidazol-4-yl)pyridine 1-oxide), a novel fatty acid amide hydrolase (FAAH) inhibitor in male and female CD-1 mice based upon raw data obtained from Bial Portela & Companhia S.A. (São Mamede do Coronado, Portugal). These studies were carried out prior to the clinical trial with BIA 10–2474 and formed part...