Dietary Choline Supplementation Attenuates High-Fat-Diet–Induced Hepatocellular Carcinoma in Mice

Hepatocellular carcinoma (HCC) is the third most common cause of cancer-related death in the world. Choline deficiency has been well studied in the context of liver disease; however, less is known about the effects of choline supplementation in HCC. The objective of this study was to test whether choline supplementation could influence the progression of HCC in a high-fat-diet (HFD)–driven mouse model. Four-day-old male C57BL/6J mice were...