Synthesis of spirooxindolocarbamates based on Betti reaction: antibacterial, antifungal and antioxidant activities

A series of new spirooxindolocarbamates 4a–l and 6a–d were synthesized by using the Betti reaction. All the target compounds were well characterized by IR, NMR and mass spectrometry. The structures of the compounds 4a and 4e were confirmed by the single crystal X-ray diffraction. The in vitro antibacterial activity results revealed that the compounds 4f exhibited excellent antibacterial activity against E. coli with MIC value 7.5 µg/mL when...