Original paper
Structural and DNA binding properties of mycobacterial integration host factor mIHF
Volume: 209, Issue: 3, Pages: 107434 - 107434
Published: Mar 1, 2020
Abstract
In bacteria, nucleoid associated proteins (NAPs) take part in active chromosome organization by supercoil management, three-dimensional DNA looping and direct transcriptional control. Mycobacterial integration host factor (mIHF, rv1388) is a NAP restricted to Actinobacteria and essential for survival of the human pathogen Mycobacterium tuberculosis. We show in vitro that DNA binding by mIHF strongly stabilizes the protein and increases its...
Paper Details
Title
Structural and DNA binding properties of mycobacterial integration host factor mIHF
Published Date
Mar 1, 2020
Volume
209
Issue
3
Pages
107434 - 107434
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Notes
History