COMPARISON OF THE EFFECTS OF DIFFERENT FATTY ACID SYNTHASE INHIBITORS ON THE CELL CYCLE, APOPTOSIS, AND MORPHOLOGY OF SQUAMOUS CELL CARCINOMA 9 CELLS

The aim of this study was to compare the effect of pharmacologic inhibition of 3 different catalytic domains of fatty acid synthase (FASN) on the cell cycle and apoptosis and associate with the morphologic alterations in squamous cell carcinoma 9 (SCC-9) cells. SCC-9 cells were treated with C75, triclosan (TCS), and orlistat (ORL) (inhibitors of KS, ER, and TE domains of FASN) for 24 to 48 hours and analyzed by flow cytometry and phase contrast...