Débora Campanella Bastos
State University of Campinas
Publications 21
Introduction Over-expression of fatty acid synthase (fasn) is associated with poor prognosis in several human cancers, including oral squamous cell carcinoma (OSCC). Objective To evaluate the effects of the fasn inhibitor TVB-3166 on the cell viability, morphology, cell cycle and migration of SCC-9 and SCC-9 LN-1 cells derived from tongue OSCC. Study Design Cell viability was determined using standard MTT assay after 48 hours of treatment with increasing doses of TVB-3166. IC50 was calculated wi...
Purpose Fatty acid synthase (FASN), the multifunctional enzyme responsible for endogenous fatty acid synthesis, is highly expressed and associated with poor prognosis in several human cancers, including melanoma. Our group has previously shown that pharmacological inhibition of FASN with orlistat decreases proliferation, promotes apoptosis, and reduces the metastatic spread of B16-F10 cells in experimental models of melanoma. While most of the orlistat antitumor properties seem to be closely rel...
Last.Massimo LodaH-Index: 1
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#1Giorgia Zadra (Harvard University)H-Index: 16
#2Caroline F. Ribeiro (Harvard University)H-Index: 1
Last.Massimo Loda (Broad Institute)H-Index: 101
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A hallmark of prostate cancer progression is dysregulation of lipid metabolism via overexpression of fatty acid synthase (FASN), a key enzyme in de novo fatty acid synthesis. Metastatic castration-resistant prostate cancer (mCRPC) develops resistance to inhibitors of androgen receptor (AR) signaling through a variety of mechanisms, including the emergence of the constitutively active AR variant V7 (AR-V7). Here, we developed an FASN inhibitor (IPI-9119) and demonstrated that selective FASN inhib...
14 CitationsSource
#1Mauricio Rocha Dourado (OUH: Oulu University Hospital)H-Index: 4
#2Johanna Korvala (University of Oulu)H-Index: 9
Last.Tuula Salo (OUH: Oulu University Hospital)H-Index: 73
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ABSTRACTAs one of the most abundant constituents of the tumour microenvironment (TME), cancer-associated fibroblasts (CAF) display critical roles during tumour progression and metastasis. Multiple ...
1 CitationsSource
Last.Edgard GranerH-Index: 36
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