Débora Campanella Bastos
State University of Campinas
Publications 16
Last.Massimo LodaH-Index: 1
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#1Giorgia Zadra (Harvard University)H-Index: 16
#2Caroline F. Ribeiro (Harvard University)H-Index: 1
Last.Massimo Loda (Broad Institute)H-Index: 101
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A hallmark of prostate cancer progression is dysregulation of lipid metabolism via overexpression of fatty acid synthase (FASN), a key enzyme in de novo fatty acid synthesis. Metastatic castration-resistant prostate cancer (mCRPC) develops resistance to inhibitors of androgen receptor (AR) signaling through a variety of mechanisms, including the emergence of the constitutively active AR variant V7 (AR-V7). Here, we developed an FASN inhibitor (IPI-9119) and demonstrated that selective FASN inhib...
14 CitationsSource
#1Mauricio Rocha Dourado (OUH: Oulu University Hospital)H-Index: 4
#2Johanna Korvala (University of Oulu)H-Index: 9
Last.Tuula Salo (OUH: Oulu University Hospital)H-Index: 73
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ABSTRACTAs one of the most abundant constituents of the tumour microenvironment (TME), cancer-associated fibroblasts (CAF) display critical roles during tumour progression and metastasis. Multiple ...
1 CitationsSource
Last.Edgard GranerH-Index: 36
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#1Bruna dos Santos Mendonça (UFRJ: Federal University of Rio de Janeiro)H-Index: 2
#2Michelle Agostini (UFRJ: Federal University of Rio de Janeiro)H-Index: 11
Last.Franklin David Rumjanek (UFRJ: Federal University of Rio de Janeiro)H-Index: 18
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Abstract MAGE-A10 is a member of the MAGE protein family (melanoma associated antigen) which is overexpressed in cancer cells. Although MAGE-A10 has been characterized for some time and is generally associated to metastasis its function remains unknown. Here we describe experiments using as models oral squamous cell carcinoma (OSCC) cell lines displaying increasing metastatic potential (LN1 and LN2). These cell lines were transduced with lentivirus particles coding for short hairpin against MAGE...
3 CitationsSource
Effects of fatty acid synthase inhibitors on lymphatic vessels: an in vitro and in vivo study in a melanoma model
8 CitationsSource