Structure of Urocanate Hydratase from the protozoan Trypanosoma cruzi
Abstract
The enzyme Urocanate Hydratase (UH) participates in the catabolic pathway of L-histidine. Trypanosoma cruzi Urocanate Hydratase (TcUH) is identified as a therapeutic molecular target in the WHO/TDR Targets Database. We report the 3D structure determination and number of features of TcUH, and compared it to other few available bacterial UH structures. Each monomer presents two domains and one NAD+ molecule. Superpositions revealed differences in...
Paper Details
Title
Structure of Urocanate Hydratase from the protozoan Trypanosoma cruzi
Published Date
Mar 1, 2020
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