Herpes simplex encephalitis in adult patients with MASP-2 deficiency
Abstract
We report here two cases of Herpes simplex virus encephalitis (HSE) in adult patients with very rare, previously uncharacterized, non synonymous heterozygous G634R and R203W substitution in mannan-binding lectin serine protease 2 (MASP2), a gene encoding a key protease of the lectin pathway of the complement system. None of the 2 patients had variants in genes involved in the TLR3-interferon signaling pathway. Both MASP2 variants induced...
Paper Details
Title
Herpes simplex encephalitis in adult patients with MASP-2 deficiency
Published Date
Dec 23, 2019
Journal
Volume
15
Issue
12
Pages
e1008168 - e1008168
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